CEACAM5 and non-small cell lung carcinoma: Doseeva et al recently confirmed the value if using a mixed panel of tumor antigens (CEA, CA-125, and CYFRA 21-1) and one autoantibody (NY-ESO-1) in the early detection of NSCLC in high-risk individuals, and they found the 4-biomarker panel was able to discriminate NSCLC cases from controls with 74% sensitivity, 80% specificity, and 0.81 AUC in the training set and with 77% sensitivity, 80% specificity, and 0.85 AUC in the independent validation set [37].