The autoantibody level of anti-ENO1 was significantly higher in sera from NSCLC patients (median ± IQR: 5.57 ± 3.38 ng/ml) than that in normal individuals (median ± IQR: 4.86 ± 2.50 ng/ml) (P=0.001, Figure 2A). This evidence concerns the gene ENO1 and non-small cell lung carcinoma.