We also considered the associations with AMD risk of 2 further variants in the APOE gene region40: rs7412, the T allele of which tags the APOE ε2 variant (per allele OR, 1.59; P = 2×10−42), and rs429358, the C allele of which tags the APOE ε4 variant (per allele OR, 1.12; P = 8×10−6). This evidence concerns the gene APOE and age-related macular degeneration.