ERBB2 and esophageal adenocarcinoma: Thus, as proof of principle, we aimed to evaluate the sequential changes in intratumoral MRI spatial heterogeneity following trastuzumab and/or cisplatin therapy in a HER2-expressing esophageal adenocarcinoma xenograft (OE19) and to compare this with histopathological changes in angiogenesis, hypoxia, and cellular proliferation.