In our study, patients with more than five years of extra ageing implied by higher scores of Arterial Index also demonstrated significant elevation of CVD Prediction Scores [9] and lowered levels of serum IGF-1, the primary mediator of growth hormone (GH) effects, which is known to influence probability to develop major cardiovascular episode, all-cause mortality and cancer mortality [40-42] and diabetes [43]. Here, GH1 is linked to diabetes mellitus.