As shown, high expression of BMP2 was significantly correlated with larger tumor size (P = 0.038), lymph node metastasis (P = 0.008), advanced clinical stages (P = 0.000), distant metastasis rate at diagnosis (P=0.01) and bone metastasis (P=0.028). This evidence concerns the gene BMP2 and metastatic malignant neoplasm in the lymph nodes.