It has been demonstrated that BMPs have an impact in cancer, but so far most of the studies have led to contradictory results implicating these molecules function as both suppressors and promoters of tumors in a context dependent manner, with a bi-directional characteristics in cancer that are similar to those of TGF-β [14-16].Therefore, the exact role of BMPs in cancer pathogenesis remains unclear. This evidence concerns the gene CLN5 and cancer.