NTRK3 and neoplasm: These results indicate that loss of TrkC reduces both the number of metastases in the lung and cell motility, in contrast to suppression of tumor formation by TrkC overexpression in a xenograft mouse model previously reported [12, 13], and these results indicate that TrkC plays a role in one or more steps of the metastatic process, which makes colonisation of distant organs more efficient.