Furthermore, the anti-inflammatory effect of febuxostat should improve insulin resistance because any decrease in plasma IL-6 is also expected to functionally improve insulin signaling in skeletal muscles at IRS-1 function, which is independent of IRS-1 and GLUT4 expression33, and restoration of adiponectin levels in VAT would also help in the recovery of systemic insulin sensitivity34. Here, IRS1 is linked to Insulin resistance.