It was found that, although all these cytokines showed elevated levels in lupus serum (Supplementary Figure 6A), only anti-IFNAR Abs were able to obviously downregulate the induction of NKG2DL Mult-1 expression (Fig. 5A), which was consistent with the finding of high IFNAR expression on Treg cells in MRL/lpr mice (Supplementary Figure 6B). The gene discussed is IFNAR1; the disease is systemic lupus erythematosus.