IFNAR1 and systemic lupus erythematosus: Yet, several studies have reported the reverse function of IFN-α in lupus mouse models30, 51, 52, indicating that there are no IFN-α signature profiles for the splenic mononuclear cells of MRL/lpr mice51, that IFNAR antibody has no effect30 and that IFNAR deletion results in even more disease in MRL/lpr mice52.