BACE1 and early-onset autosomal dominant Alzheimer disease: Conversely, the AP of hAPP was favoured at the expense of sAPPα extracellular shedding following overexpression of BACE1/β-secretase40 or the Swedish mutant form of hAPP (SweAPP), which is linked to a familial EOFAD and is more effectively cleaved by BACE1/β-secretase within the TGN69.