DDX41 and Alzheimer disease: The typical markers of AD are senile plaques, i.e., accumulations of amyloid-β peptides (Aβs) in the neuropil; neurofibrillary tangles (NFTs), i.e., insoluble clusters of hyperphosphorylated Tau proteins inside neurons; the loss of synaptic contacts; neurotoxicity; increased cell death in neurons and oligodendrocytes; activated astrocytes and microglia; chronic neuroinflammation; cerebrovascular damage; and blood-brain barrier dysfunction2–4.