CASR and Alzheimer disease: Moreover, as AD progression in the human brain is coupled with diffuse, chronic neuroinflammation65, we sought to determine whether a calcilytic might still antagonize the noxious effects of fAβ25–35•CaSR signalling when a microglial cytokine mixture trio (CMT; i.e., IFN-γ, TNF-α, and IL-1β) was also administered58.