ATF4 and Hepatic fibrosis: For example, genes implicated in cytoplasmic nuclear receptor activation, glutathione-mediated reactions, nuclear factor 2 (NRF2)-mediated oxidative stress, triglyceride, ethanol and amino acid degradation, fatty acid oxidation, acute phase response, cytochrome P450-mediated reactions, bile acid synthesis, and hepatic fibrosis were altered in both Gcn2−/− and Atf4−/− mice.