SYNE1 and muscular dystrophy: To determine how mutations known to alter the functional integrity of LINC complexes affect the ability of muscle cell precursors to match their cytoskeleton tension to the stiffness of the microenvironment, we have used human myoblasts with LMNA29, 34 or SYNE-1 mutations35, 36 (hereafter named LMNAΔK32 and Nespr-1ΔKASH myoblasts, respectively) responsible for severe muscular dystrophies.