As shown in Table 4 and Fig. 3B, there was a trend for an increased OR of having exudative AMD with decrease of DKK-1 quartile (χ2 = 39.769, P = 0.000): The third versus upper quartile of DKK-1 levels (OR, 3.02, 95% CI [1.38–6.6]; P = 0.006); The second versus the upper quartile of DKK-1 levels (OR, 5.81, 95% CI [2.68–12.6]; P = 0.000); The lowest versus upper quartile of DKK-1 levels (OR, 11.71, 95% CI [5.24–26.13]; P = 0.000). Here, DKK1 is linked to age-related macular degeneration.