SMAD3 and Marfan syndrome: Studies have reported that mutations within the TGF‐β signaling pathway can result in a number of inheritable connective tissue disorders, including the increased systemic TGF‐β observed in Marfan syndrome, the mutated TGF‐β receptors seen in Loeys‐Dietz syndrome, or the altered downstream TGF‐β canonical signaling noted in Smad3 deficiency (Braverman 2013; Guo et al.