DLL4 and neoplasm: On the other hand, recombinant ligands such as Dll1, Dll4 (Hicks et al, 2002; Lefort et al, 2006; Mohtashami et al, 2010; Xu et al, 2012; Castel et al, 2013), and JAG1 (Sato et al, 2009; Van Landeghem et al, 2012; VanDussen et al, 2012; Yamamura et al, 2014; Mahapatro et al, 2016; Srinivasan et al, 2016) have been reported to activate Notch signaling in various cell types, including intestinal organoids and tumor spheroids.