In this study, these cytotoxic forms of MLKL phosphorylated at Thr357 and Ser358 were detectable in all HF samples supporting the implication of RIP1, RIP3 and p-Ser227-RIP3 expression data and the hypothesis that this cell death mode might be involved in the pathogenesis of HF [11]. This evidence concerns the gene RIPK1 and hydrops fetalis.