We studied the synergism of PARP1 inhibitors and trabectedin in a large set of different tumor cell lines and in in vivo models, demonstrating that PARP1 inhibition improved the antitumor activity of trabectedin in a cell-line dependent intensity, as previously shown in breast cancer and in Ewing’s sarcoma cell lines [44, 55]. Here, PARP1 is linked to Ewing sarcoma.