To generalize to other tumor settings our observations on PARP1 inhibition, we tested trabectedin + olaparib activity in an independent panel of 11 tumor cell lines of different origins (prostate, lung, bile duct, breast), and verified a direct correlation between PARP1 protein expression and combination synergy (Fig. 6a, Additional file 1: Table S2). The gene discussed is PARP1; the disease is neoplasm.