Ali, A et al. [44] investigated the signaling pathways that interact with KLF17 in the suppression of tumor progression, and the results showed that KLF17 plays an integral role in potentiating TGF-beta/Smad signaling via the Smad3-dependent pathway, thus providing a new model of signal pathway regulation by KLF17 in the progression of invasion or metastasis of tumor cells. The gene discussed is KLF17; the disease is neoplasm.