Furthermore, KLF17 inhibited the expression of Phospho- p38/MAPK and Phospho-Src, the inhibition of p38/MAPK blocked the KLF17-induced suppression of uPA, and the inhibition of Src enhanced the KLF17-induced suppression of uPA, therefore suggests that KLF17 suppress the expression of uPA to inhibit lung adenocarcinoma invasion via the p38/MAPK and Src pathways. The gene discussed is PLAU; the disease is lung adenocarcinoma.