As seen in the overexpression of uPA in various human cancers, Krüppel-Like Factor 17 (KLF17) is also downregulated in human cancers, including lung cancer [23], liver cancer [24], gastric cancer [25], papillary thyroid carcinoma [26], esophageal carcinoma [27], and colorectal carcinoma [28], and reduced expression of KLF17 is associated with poor prognosis in these patients. This evidence concerns the gene PLAU and liver cancer.