PDE3B and intrahepatic cholangiocarcinoma: As discussed above, PDE3A – and not PDE3B – was prominent in mouse ICC and data mining using MERAV (Metabolic gEne RApid Visualizer)http://merav.wi.mit.edu/, that allows comparison of gene expression across human tissue and cell types [38], indicates that PDE3A appeared to be more highly expressed than PDE3B in primary GIST tumors (Supplementary Figure 4).