AFP and neoplasm: The prognostic significance of HOXB7 persisted in HCC patients with a single tumor (P=0.001), without vascular invasion (P<0.001), BCLC stage 0+A (P=0.001), with normal AFP levels (P=0.01), small tumor size (diameter ≤5 cm) (P=0.01), without satellite lesion (P<0.001) and with well-differentiated tumor (Edmonson stage I-II) (P<0.01) (Figure 6C-6F and Supplementary Figure 4).