In this study, we observed the expression of CXCR1 in normal breast tissues, breast fibroadenoma tissues and breast cancer tissues to see its expression in different breast diseases and detected the expression changes of CXCR1 in breast cancer tissues before and after neo-adjuvant chemotherapy in patients with breast cancer, in order to explore its correlation with the efficacy of neo-adjuvant chemotherapy. This evidence concerns the gene CXCR1 and breast cancer.