Prokineticin 2 and PROKR2 are both expressed in the hypothalamus and pituitary, and reduced expression or activity of PROKR2 is implicated in both Kallmann syndrome and PSIS, perhaps because of the important role this signaling pathway plays in endocrine angiogenesis and neuronal migration in this region of the central nervous system. This evidence concerns the gene PROKR2 and Kallmann syndrome.