The same heterozygous mutation on PROKR2 that was identified in the proband here, c.253C>T;p.R85C, has also been found in a female patient with combined pituitary hormone deficiencies, including in GH, adrenocorticotropic hormone, luteinizing hormone, and follicle-stimulating hormone, as well as vasopressin, and magnetic resonance imaging demonstrating normal anterior pituitary, absent posterior pituitary, and absent stalk (20). The gene discussed is GH1; the disease is hypopituitarism.