In mice, TReg populations expressing αE have been identified and shown to suppress inflammation in a number of disease models, including colitis,17 chronic graft versus host disease18 and antigen-induced arthritis.15 In human UC and control subjects we found CD4+αE+ lymphocytes have reduced transcription of the regulatory T cell-associated gene FOXP3 relative to their CD4+αE− counterparts. This evidence concerns the gene CD4 and colitis.