Genomic regions and variants previously implicated in Mendelian RBC disorders include the African ancestral alleles for sickle cell trait/anemia or hemoglobin S (HBB rs334); hemoglobin C (HBB rs33930165); the common African form of G6PD A- deficiency (rs1050828); the 3.8kb alpha-globin gene deletion responsible for alpha-thalassemia trait (esv2676630); and a proxy SNP (rs2032451) for the European hereditary hemochromatosis (HFE) p.H63D allele. Here, HBA2 is linked to Alpha-thalassemia.