The HBB rs334, HBB rs33930165, esv2676630 alpha-globin 3.8kb gene deletion, and G6PD rs1050828 lead variants are derived from an African ancestral background, while the HFE hemochromatosis variant rs2032451 (proxy of rs1799945 p.H63D) is common among Europeans and Amerindian populations and much less common among Asians and West Africans. The gene discussed is G6PD; the disease is hemochromatosis.