TP53 and non-small cell lung carcinoma: We induced formation of NSCLC in the transgenic KRastm4Tuj/Trp53tm1Brn mouse model [11, 12] by inhalation of adenovirus bearing the Cre recombinase at post-natal week 10 [13], causing activating mutation of KRas in parallel with inactivation of Trp53. Beginning at 11 weeks of age, mice received weekly injections of 150 mg/kg STA-8666 or of vehicle.