The shape of funnel plots showed a nearly symmetrical distribution, indicating no evidence of publication bias in all genetic models (Fig 6).Egger’s test also reveal no statistical significance for evaluation of publication bias under recessive model for H. pylori infection risk [IL-1B-31C/T: P = 0.275, IL-1B-511C/T: P = 0.06, IL-8-251A/T: P = 0.184], for H. pylori-related GC [IL-1B-511C/T: P = 0.781, IL-8-251A/T: P = 0.88], for H. pylori-related PUD [IL-8-251A/T: P = 0.71]. Here, IL1B is linked to gastric cancer.