Among the enrolled studies, three studies focus on the risk of H. pylori infection GC patients for IL-1B-31C/T, six studies focus on the risk of GC in H. pylori infection individuals for IL-1B-511C/T, three focus on the risk of GC in H. pylori infection individuals for IL-8-251T/A, five focus on the risk of PUD in H. pylori infection individuals for IL-8-251T/A. Here, CXCL8 is linked to gastric cancer.