Lastly, A549 lung carcinoma cells that overexpress either isoform of WDR23 have reduced expression of the NRF2 targets GSTA (Fig 6D) and PRDX1 (Fig 6E), which are often induced in cancer cells and have been identified as potential targets for directed therapy[74, 75]. This evidence concerns the gene NFE2L2 and lung carcinoma.