We detected no activation of these pathways [TGF‐β/SMAD (Xu et al., 2008), IL‐6/STAT3 (Kim et al., 2013), and OCT4 stabilization by AKT (Lin et al., 2012)] in CRC cells treated by CM from LPEC (data not shown). Here, AKT1 is linked to colorectal carcinoma.