Hypermethylation of CSMD2 in pancreatic cancer37 or its low expression in colorectal cancer was significantly associated with differentiation, lymphatic invasion, tumor size and overall survival.38CLSTN2 encodes the synaptic protein calsyntenin 2 and is related to human memory and hippocampal function.39DYSF is highly expressed in the skeletal muscle and has been suggested to be involved in membrane regeneration and repair. Here, CSMD2 is linked to colorectal cancer.