KDM1A (also known as LSD1) is associated with the maintenance and differentiation of HSCs by demethylation of H3K4me2.29KDM1A is upregulated in prostate cancer or neuroblastoma, and its expression has been reported to correlate with adverse outcome or inversely correlate with differentiation in tumors. The gene discussed is KDM1A; the disease is neuroblastoma.