CSMD2 and neoplasm: Hypermethylation of CSMD2 in pancreatic cancer37 or its low expression in colorectal cancer was significantly associated with differentiation, lymphatic invasion, tumor size and overall survival.38CLSTN2 encodes the synaptic protein calsyntenin 2 and is related to human memory and hippocampal function.39DYSF is highly expressed in the skeletal muscle and has been suggested to be involved in membrane regeneration and repair.