Moreover, deep sequencing revealed that the ASXL1 mutation of patient #12 at diagnosis had disappeared once MMR was achieved, while Boultwood et al. also reported ASXL1 mutations in four patients with CML-CP.18 These results suggest that an ASXL1 mutation indicate the disease state or prognosis of CML. Here, ASXL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.