Furthermore, the antitumor effect of HT could be exerted through down-regulation of epidermal growth factor receptor (EGFR) expression, as shown in human colon tumor cells in which HT induced ubiquitination and degradation of the receptor, effects that are associated with a decrease in cell proliferation, thus complying with its anti-cancerous effect [48]. This evidence concerns the gene EGFR and colonic neoplasm.