Moreover, in the study by Pirozzi et al. [42] using HT supplementation (10 mg/kg/d) in rats with HFD-induced NAFLD, protective effects against liver damage caused by HFD were observed, including an anti-inflammatory action, improved glucose tolerance, increased insulin sensitivity, decreased OS, and reduced plasma cholesterol, increasing the hepatic levels of PPAR-α (Table 1). This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.