MUC16 and ovarian carcinoma: Other investigators modeling the levels of CA-125 associated with the smallest progressing ovarian cancers reported that these cancers could develop unnoticed for 10.1 years and presented the view that the largest tumor below the resolution of ultrasound (0.5 cm diameter) could progress to a detectable size (1.2–2.5 cm) in 1–2 years [47].