Within the top 5 genes repressed by LDAA (lowest P values), SNRK-AS1 is potentially involved in colon-cell proliferation, PLTP modulates inflammation and immune responses and C1orf56 (MENT) is a tumor modifier associated with lymphoma; the top 5 overexpressed genes were associated with activation of host-defense responses and hematopoiesis (see Tables S2 and S3, Supplemental Digital Content 1, http://links.lww.com/IBD/B503). The gene discussed is C1orf56; the disease is lymphoma.