DNMT1 and cancer: Secondly, MENT is associated with lymphomagenesis in mice, and decreased methylation activity upregulates MENT expression.49 Noting that thiopurines decrease DNMT activity,50 and aside from the possibility that lower dTGDNA with LDAA may reduce secondary cancer risk, the evidence for downregulation of MENT by LDAA suggests that the elevated lymphoma risk associated with thiopurine therapy in elderly patients51 may be avoided using LDAA rather than standard-dose azathioprine.