Indeed, clinical administration of an NF-κB decoy to patients with atopic dermatitis resulted in no major adverse effects on the immune response.52, 53 On the other hand, western blot analyses showed that the NF-κB decoy ODN suppressed the protein expression of IL-1β, IL-6 and ICAM-1 in healthy gingival tissues. The gene discussed is ICAM1; the disease is atopic eczema.