NFKB1 and bacterial infectious disease: For example, while the effects of NF-κB transfection into healthy gingival tissue were the main focus of this study, the effects of such transfection on periodontal lesions and diseased tissue should be examined using mouse models of periodontal inflammation, bacterial infection or systemic inflammation to elucidate the potential applications for this methodology of drug delivery in clinical cases of periodontal disease.