A recent study in the Adenomatous Polyposis Coli (Apc)+/− murine model of intestinal carcinogenesis showed that Hmga1 is downstream of the miR-26 tumour suppressor60, suggesting that APC mutations in colorectal cancer lead to HMGA1 induction through loss of miR-26. The gene discussed is HMGA1; the disease is colorectal cancer.