Multivariate survival analysis to evaluate the impact of other factors on survival including lymph node stage, grade, tumour size, ER status and HER2 status found that in both the full and ER-positive cohorts, CDC42 nuclear staining was not an independent prognostic factor (p = 0.17, p = 0.086, respectively, Table 3). The gene discussed is CDC42; the disease is neoplasm.