FMR1 and fragile X syndrome: Humans with FXS show evidence of auditory hypersensitivity, disrupted preattentive stimulus recognition, and altered novelty detection by EEG (St Clair et al. 1987; Castrén et al. 2003; Van der Molen et al. 2012a, b; Ethridge et al. 2016), as do Fmr1 KO mice (Chen and Toth, 2001; Frankland et al. 2004; Gibson et al. 2008; Lovelace et al. 2016).