Mutations of p97 are causative of three protein aggregation diseases (proteinopathies; reviewed in Tang and Xia, 2016): Multisystem Proteinopathy (MSP), Familial Amyotrophic Lateral Sclerosis (FALS) and Charcot-Marie-Tooth Disease, Type 2Y (CMT2Y). This evidence concerns the gene VCP and Charcot-Marie-Tooth disease type 2Y.