For example, in only one out of eight non-small-cell lung cancer (NSCLC) patients who were confirmed to have an EGFR mutation could the mutation be detected in the bulk CTC population.80 Single CTC profiling can overcome the restriction proposed by blood cell contamination, enabling the study of CTC heterogeneity.81 Recent research has shown a growing trend in CTC capture and single-CTC analysis in sequence or simultaneously. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.