ZFP36L2 and neoplasm: The probe utilizes lanthanide luminescence and it was designed based upon the tandem zinc finger RNA binding domain (RBD) of TIS11d (also called ZP36L2), a protein of the tristetraprolin (TTP, also called ZP36) family that plays critical roles in mRNA regulation by simultaneously regulating multiple cytokines associated with inflammation (e.g. TNFα) and also functions as a tumor suppressor.38–40 The probe was obtained by chemical synthesis, is selective for the target mRNA sequence and exhibits a similar binding affinity compared to that of the native TIS11d RBD with the same RNA target.