MME and neoplasm: Chen et al. utilised a highly functionalised mesoporous silica nanoparticle (MSN) to successfully image tumour vasculature in vivo using a multimodal approach which employed both PET and optical imaging techniques.117 To target the nanoparticles, the group attached a Fab fragment targeted against CD10, a vascular-specific marker for tumour angiogenesis, and demonstrated a significant improvement in both PET and fluorescence imaging resolution in vivo compared to non-targeted controls.