GPT and familial hypercholesterolemia: Increased levels of ALT, AST, and alkaline phosphatase were documented in respectively 9.5%, 9.8% and 9.1% of overweight subjects, and 16.9%, 14.9% and 10.8% of obese individuals.20 The first survey of the CASPIAN study revealed that those children with hypertriglyceridemic waist phenotype were more likely to have cardiovascular risk factors, especially overweight and hypercholesterolemia.23