OFD1 and cystic kidney disease: However, we demonstrate that: a) components of the translation machinery localize to the centrosome in mammalian cells; b) the centrosomal protein OFD1 physically interacts with proteins involved in translation regulation; c) OFD1 cooperates with the mRNA binding protein Bicc1, which is also involved in renal cystic disease, to functionally control the translation of specific mRNA targets.