Although it is well known that p38- and ERK-MAPK in AM or PMB are upregulated upon mycobacterial infection or mycobacterial components, it is essential to delineate the precise mechanisms underlying the inhibitory effects of HSP70 on NF-κB activity by investigating the basal expression of MAPK before and after HSP70 overexpression in AM or peripheral monocytes before and after anti-TB treatment. This evidence concerns the gene NFKB1 and tuberculosis.