CCN5 and hepatocellular carcinoma: To address the unmet issues and establish the anti-invasive role of CCN5, in this study, we selected TNBC cell lines (i.e., MDA-MB-231 and HCC-70), which are an enriched source of TICs with stem cell properties and isolated SP and NSP cells from MCF-7, and we examined the impact of CCN5-signaling on functions and survival of these cells under in vitro and in vivo settings using human recombinant CCN5 protein (hrCCN5) treatment and genetic manipulation.