Given their enhanced lymph node and tissue homing receptor expression, it is tempting to speculate that these cells are generated following reprogramming within the inflamed liver and subsequently home to extrahepatic and circulatory compartments where they serve to suppress antimicrobial responses.43 Further work is required to delineate the recruitment and subsequent fate of MerTK-expressing myeloid cells during acute liver injury. Here, MERTK is linked to injury.