Studies on IL-1 expression in established human melanoma cell lines are inconsistent, ranging from constitutive IL-1β expression and secretion only in metastases-derived cells (Okamoto et al., 2010) to constitutive IL-1α and IL-1β expression in the majority of melanoma cell lines independently of disease stage (Qin et al., 2011) and to no IL-1β secretion at all because of lack of expression of one or more inflammasome components (Gehrke et al., 2014). This evidence concerns the gene IL1B and melanoma.