IL1R1 and melanoma: To test the importance of IL-1 signaling within the host stroma for melanoma growth, we injected 4434 BrafV600E melanoma cells, derived from melanoma-bearing BrafV600E mice (Dhomen et al., 2009), into either syngeneic control mice (Il-1r1fl/fl) or recently generated Il-1r1−/− mice that lack both IL-1R1 and the truncated isoform IL-1R3 and thereby display total disruption of IL-1 signaling (Abdulaal et al., 2016).