As IL-6, IL-8, and GROα have already been demonstrated to be important cytokines for melanoma growth and progression (Schadendorf et al., 1993; Bar-Eli, 1999; Haghnegahdar et al., 2000; Huang et al., 2002; von Felbert et al., 2005; Varney et al., 2006), this provides a link between IL-1 signaling in the stroma and melanoma growth support. This evidence concerns the gene IL1B and melanoma.