MAPK8 and Immunodeficiency: For the heat map with the immunity-related genes, we included genes from the four known immune signaling pathways [Immune Deficiency (IMD), Janus Kinase and Signal Transducer and Activator of Transcription (JAK/STAT), cJun- N-terminal Kinase (JNK), and Toll], genes involved in cellular immune responses and hematopoiesis, immune-induced molecules, genes with immune receptor activity, and genes with general immune functions, which also included genes with putative immune roles (Figure 4A).