Of interest, Cathepsin S overexpression is not a general feature of neurodegenerative processes since only slight mRNA upregulation was detected in early AD stages and in PD/LBD cases, thus our work sets an important basis for future studies addressing the true contribution of Cathepsin S in the neuroinflammation processes associated with sCJD pathogenesis. This evidence concerns the gene CTSS and Alzheimer disease.