For example, dihydroorotase, found at rank 2 (4C6E_2, Tanimoto coefficient 0.3297, Z-score 3.08), is a protein associated to congenital hypoplastic anemia, an inborn condition characterized by deficiencies of red cell precursors that sometimes also includes leukopenia and thrombocytopenia. Here, CAD is linked to Decreased total leukocyte count.