CAD and Blackfan-Diamond anemia: For example, dihydroorotase, found at rank 2 (4C6E_2, Tanimoto coefficient 0.3297, Z-score 3.08), is a protein associated to congenital hypoplastic anemia, an inborn condition characterized by deficiencies of red cell precursors that sometimes also includes leukopenia and thrombocytopenia.