HLA-C and type 1 diabetes mellitus: Similarly, in CeD, which has the same main associated haplotype as T1D, the HLA-DQ-DR locus explains 23 − 29% of disease variance (depending on the estimated prevalence of disease, which is 1 − 3%), whereas other MHC alleles explain 2 − 3%, and non-MHC loci explain 6.5 − 9% [35].