At low magnification (20x) accumulation within cells in the connective tissue in the stroma was observed (Fig 5A), but uptake into individual CHL-1 HER3 expressing tumor cells was clearly distinguished at high magnification (63x) as distinct punctate signal within the cytoplasm (arrows in Fig 5C, 5D and 5E). The gene discussed is ERBB3; the disease is neoplasm.