ERBB3 and neoplasm: The biodistribution experiments of GSK2849330 showed that the uptake in tumor is affected not only by the HER3 expression level at the tumor but also by the complexity of the biological system which includes the expression level of the HER3 and FcγRs receptors in other organs, the vasculature density in the tumor lesions which may affect the transport, the clearance of the monoclonal antibody, and the dose and the timing of the treatment.